T3P® – Propanephosphonic Acid Anhydride

T3P® – Propanephosphonic Acid Anhydride  

T3P® is an exceptional reagent for amide/peptide bond formation.  Further, recent research has extended the application of this reagent to other condensation reactions, such as esterifications, and as a mild reagent for alcohol oxidations and the Lossen rearrangement.  T3P® is very easy to use and provides excellent selectivity, low epimerization and high yields with simple product isolation by liquid/liquid extraction. Due to its high selectivity hazardous additives, such as explosive HOBt, are not required. Additionally, the T3P® reagent is “green”, being non-toxic, non-allergenic/non-sensitizing, and the salt by-products are non-hazardous and completely water soluble.  T3P® is well established at large scale for challenging liquid phase amide/peptide coupling reactions and other condensation reactions where its advantages translate into high quality products and improved economics.

Advantages of T3P®

  • Safe handling: no CMR properties, non-toxic, no allergenic/sensitizing properties
  • Wide range of other condensation reactions possible
  • Several pharma applications up to 100 ton scale
  • Reduced overall process costs 
  • Easy purification/workup 
  • Low epimerization during coupling
  • No additives required
  • Standard peptide couplings can be done in many different solvents and with common protecting groups
  • Broad functional group tolerance, mild reaction conditions, high yields
Attachments:
Download this file (EUTICALS_T3P.pdf)T3P® Brochure - Euticals206 kB


Euticals S.p.a.
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